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Genetic model assumptionsPharmacokinetic studies using different CYP2C19 substrates indicate an additive or dominant mode of inheritance of the loss of function metaboliser trait, showing either a per allele decrease in enzymatic activity27 or https://www.belstaffmotorcyclejacketssale.co.uk a similar drop of activity in carriers of one or two loss of function variants compared with non carriers.28 29 Pharmacokinetic studies assessing the metabolic activity of CYP2C19 in relation to the gain of function CYP2C1917 variant likewise indicate either additive inheritance with a per allele increase in activity between 1/1, 1/17, and 17/17 carriers30 or dominant inheritance with a similar gain of the enzymatic activities in carriers of one or two 17 alleles compared with wild type 1/1 carriers.31
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